MAMMALIAN CELLS & mAb‘s
8Pages

MAMMALIAN CELLS & mAb‘s DEPTH FILTRATION FOR VALUABLE LIQUIDS. SINCE 1938.

Table of contents Clarification of Mammalian Cells & mAb‘s: Background, Challenge, Solution page 3 Single-use approach of clarification page 5 Traditional approach of clarification page 7

Clarification of Mammalian Cells & mAb’s The Background Biological products such as monoclonal antibodies (mAb), hormones or enzymes are often produced by means of mammalian cells (e. g. CHO cell culture). Nowadays, mammalian cell culture is a key technology in many biotechnological processes. After the expression of the desired product in a bioreactor, the suspension is clarified in order to remove cells, cell debris, and impurities. For the clarification/harvest step, different approaches are possible. The typical clarification process involves a primary and a secondary clarification...

PURACAP® BIO SD capsules: size 2", 5" and 10"

FILTROX Single-use Clarification Approach Small scale Buffer tank figure 1 PURADISC® BIO SD filter module 2" for lab trials, 5" for batches up to 10 L, 10" for batches up to 25 L Adaptable to user needs Removal of cells and cell debris 12M, 12S, 12D and 16D depth filter modules in a bag with space to build a filter cake Adaptable to user needs Removal of cells and cell debris in pilot and production scale 30 g to 15 kg pharma grade diatomaceous earth (DE) Pharma grade filter aid Avoids clogging of the filter, increases the filterability up to 4 times Stainless steel support housing for...

FILTROX depth Filtration in the Traditional clarification approach Large filter area on a small footprint Depth filter modules and filter sheets allow large filter areas to be handled easily thanks to their compact design. Flexible Optimization Various PURAFIX® grades are available, from coarse to sterile filtration. This enables you to find the right solution for your process. Linearly Scalable Depth filtration technology is easily scalable due to its linearity. The filter material is identical from lab scale to production scale. FILTROX offers depth filtration systems for any size of...

Small/medium scale Buffer tank PURADISC® filter module DISCSTAR® LS PURADISC® filter module Buffer tank PURADISC® filter module Buffer tank PURAFIX® filter sheets NOVOX® CP PURAFIX® filter sheets Buffer tank PURAFIX® filter sheets Low ion and low pyrogen containing filter sheets Sizes between 6 cm round and 1.2 × 2.4 m possible Clarification of high value liquids Filter modules in 12" and 16" with PURAFIX® sheets Clarification of high value liquids Housing for filter modules For 1 to 4 modules (with up to 16 lenses per module) Depth filtration of turbid solutions Horizontal housing for...

Filter Presses and Module Housings Filter modules are mounted within a enclosed housing DISCSTAR®, which minimizes oxygen uptake during filtration. Flat sheets are used in open systems like the NOVOX® series. DISCSTAR® BIO SD 12" double support system DISCSTAR® H horizontal housing for filter modules DISCSTAR® LS vertical housing for filter modules NOVOX® CP sheet filter