PLASMID DNA
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CLARIFICATION SOLUTIONS FOR •PLASMID DNA r* DEPTH FILTRATION FOR VALUABLE LIQUIDS. SINCE 1938.

Clarification of Plasmid DNA The Background The increased use of gene and cell therapy, e. g. for immunotherapies with modified T cells, leads to a higher demand for recombinant viral vectors. These types of therapies are based on the use of adeno-associated viruses (AAV), lentiviruses or other virus types. Plasmid DNA is used here as starting material for the transient expression. Due to the clinical success and the growing number of late-phase clinical studies, the demand for plasmid DNA is increasing too. As a result, there is a need for larger manufacturing capacities. In order to meet...

The Solution The PURADISC® BIO SD system is the state-of-the-art technology for alluvial filtration. It is based on depth filters that capture contaminants in their three-dimensional matrix. The used PURAFIX® depth filter sheets are low in extractable ions and pyrogens. By adding filter aid, such as diatomaceous earth, the capacity per m2 filter area can be drastically increased. Product Size Description Batch size Best use PURACAP® BIO SD 2" Capsule Lab scale PURACAP® BIO SD 5" Capsule Small pilot scale PURACAP® BIO SD 10" Capsule Pilot scale PURADISC® BIO SD 12M Module Pilot scale Process...

Filter Presses and Module Housings PURADISC® BIO SD is used in combination with a pressure housing DISCSTAR® BIO SD. FILTROX offers the corresponding pressure housings for the different module sizes and filter presses for filter sheets. DISCSTAR® BIO SD 12" short support system DISCSTAR® BIO SD 12" double support system NOVOX® sheet filter